Rebozo Technique Effectively Reduces Maternal Pain during Childbirth Stage 1 Active Phase

Background: Pain is the main complaint felt by mothers during childbirth. Pain management can be done with non-pharma-cological techniques, one of which is using the Rebozo technique. Objective(s): This study aimed to determine the effectiveness of the rebozo technique for active phase 1 labour pain in primipa-rous women. Method(s): The study used a quasi-experimental design with a pretest and posttest control group. An accidental sampling technique divided a sample of 30 people into control and intervention groups. The intervention group received Rebozo therapy, a therapy using a traditional cloth wrapped around the pelvis and buttocks with the mother kneeling, then shaking it slowly. The pain was measured using the Visual Analogue Scale (VAS), ranging from 0-10. Bivariate test using Wilcoxon. Result(s): The majority of respondents were aged 21-29 years (56.7%), had high school education (83.3%) and were house-wives (50%). The majority of the control group showed moderate pain (53.3%), while the intervention group showed severe (60%). The reduction in pain in the intervention group was more significant than in the control group (2.27 > 0.73). Both the control group and the intervention group showed p < 0.001. Conclusion(s): The Rebozo technique effectively reduces labour pain in the active phase of the first stage in primiparous women. This technique is easy and inexpensive, so it can be an option for non-pharmacological therapy to treat labour pain.Copyright © 2023 Japan University of Health Sciences.

Antibody levels of COVID-19 vaccine: A comparison between healthy subjects and psychiatric patients on antidepressants

This study compares the serological antibody level post-COVID-19 vaccine among healthy subjects and psychiatric patients on antidepressant therapy. It also examines the difference in antidepressants' side effects experienced by psychiatric patients following the completion of two vaccine doses. A comparative posttest quasi-experimental study was conducted among healthy subjects and psychiatric patients on antidepressant medication in a teaching hospital in Malaysia. Elecsys Anti-SARS-CoV-2 assay was used to detect the antibody titre between weeks 4 and 12 post vaccination. The antidepressant side-effect checklist (ASEC) was used to monitor the occurrence of antidepressant-related side effects pre-and post-vaccination. 24 psychiatric patients and 26 healthy subjects were included. There was no significant difference in the antibody level between the patients (median = 1509 u/ml) and the healthy subjects (median = 995 u/ml). There was no significant worsening in the antidepressant-related side effects. The antibody level post-COVID-19 vaccine did not differ significantly between patients on antidepressant therapy and healthy subjects. Additionally, there was no change in the antidepressant side effects experienced by the patients following the completion of the vaccine.Copyright © 2022, Research Trends (P) LTD.. All rights reserved.

Perception of pharmacy students towards blended pedagogy in 21st century pharmacy education

Background: In industrialized and developing economic countries like India, the technology transfer has significantly enhanced the quality of higher education, where the tentacles of digitalization have deeply entered education system, which opened the gateway of blended pedagogy, enabling a greater access to course content, learning preparation in peers and interactions. Across the globe, blended learning is applied in pharmaceutical education but it gained momentum in Indian pharmacy education during the global threat, COVID-19 pandemic. Aim and Objectives: The current experimental study of six months duration was performed to investigate the perception of pharmacy students towards blended pedagogy in pharmacy education at undergraduate level. Methodology: In the current experiment survey, a validated standard self-administered questionnaire with 28 inventories under 7 categories was administered to students pursuing undergraduate pharmacy programs in a pharmacy institute located at rural Andhra Pradesh for a period of six months, through online mode;data collection was performed in students showing willingness and further collected data was assessed through excel spreadsheet. Result(s): The study observed a two-third satisfaction on an average in terms of all the indicators which influence the blended pedagogy (teacher 71.8%, course content 74.8%, technology transfer 58.7%, interactions 78.8%, and constructive knowledge 73.7%). Conclusion(s): In conclusion, our study envisaged effective student engagement, with more facilitator-student interactions and adaptability;through blended learning which enabled, enhanced and transformed students to active learners.Copyright © 2023, Indian Pharmaceutical Association. All rights reserved.

An Online Intervention Promoting HIV Testing Service Utilization Among Chinese men who have sex with men During the COVID-19 Pandemic: A quasi-experimental Study.

The COVID-19 pandemic created disruptions in HIV testing service utilization among men who have sex with men (MSM). The present study was to evaluate the effectiveness of an online health promotion program implemented by a community-based organization (CBO) in increasing the uptake of any type of HIV testing and home-based HIV self-testing (HIVST) over a six-month follow-up period. Participants of an observational prospective cohort study conducted during the same period served as the comparison group. This study was conducted between September 2020 and December 2021. Participants were Chinese-speaking adult MSM who were HIV-negative/unknown sero-status recruited through multiple sources in Hong Kong, China. Participants in the intervention group were exposed to the following health promotion components: (1) viewing an online video promoting HIVST, (2) visiting the project webpage, and (3) having access to a chargeable HIVST service implemented by the CBO. Among 400 and 412 participants in the intervention group and the comparison group, 349 (87.3%) and 298 (72.3%) completed follow-up evaluation at Month 6. Multiple imputation was used to replace missing values. At Month 6, participants in the intervention group reported significantly higher uptake of any type of HIV testing (57.0% versus 49.0%, adjusted odds ratios [AOR]: 1.43, p = .03) and HIVST (25.8% versus 14.8%, AOR: 2.04, p = .001), as compared to those in the comparison group. Process evaluation of the health promotion components for the intervention group was positive. Promoting HIVST is a potentially useful strategy to increase HIV testing service utilization among Chinese MSM during the pandemic.

Experimental and Clinical Evaluation of Mefloquine Effectiveness against the Infection Caused by Sars-Cov-2

The efficacy of mefloquine has not been studied in the in vivo experiments and clinical trials involving COVID-19 patients. The study was aimed to assess the effects of mefloquine on the SARS-CoV-2 accumulation in the lungs of infected animals and to study the efficacy and safety of mefloquine compared to hydroxychloroquine in patients with COVID-19. During the experiment, a total of 96 Syrian hamsters were infected with SARS-CoV-2. Accumulation of the virus in lungs was compared in the groups of animals treated with mefloquine and ribavirin and in the control group. During the clinical trial, the mefloquine and hydroxychloroquine safety and efficacy in patients with mild and moderate COVID-19 (172 individuals) was assessed based on the symptom changes over time and the computed tomography results. The experiment showed that the SARS-CoV-2 accumulation in the lungs of Syrian hamsters 6 days after infection and mefloquine treatment was 2.2 +/- 0.18 lg PFU/g, which was lower (p < 0.05) than in the control group (3.5 +/- 0.21 lg PFU/g) and ribavirin group (5.2 +/- 0.05 lg PFU/g). During the clinical trial, it was found that 50.0% of patients in the mefloquine group and 32.4% in the hydroxychloroquine group (p < 0.05) developed a mild disease, and the completely resolved respiratory failure was registered in 76.5% and 44.6%, respectively (p < 0.001). Adverse events were observed in 86.7 % and 77% of patients in the mefloquine and hydroxychloroquine groups, respectively (p > 0.05). Thus, during the experiment, mefloquine contributed to the faster virus titer reduction in the lungs. During the clinical trial, the mefloquine efficacy was non-inferiority or, based on a number of indicators, higher compared to hydroxychloroquine, with comparable safety.Copyright © Extreme Medicine.All right reserved.

Challenges and strategies to stay physically active in the face of COVID-19 pandemic: A review

The pandemic caused by the COVID-19 has influenced peoples' lifestyles. Home-confinement scenario might impair physical activity practice, resulting in new challenges for maintaining health during the pandemic of the COVID-19. The aim of this study was to present the current context of COVID-19 pandemic, its impact on the practice of physical activity, and the strategies available to remain active during home-confinement according to international recommendations. The narrative review was conducted based on studies that analyzed themes related to physical activity and COVID-19. Virtual Health Library (VHL), CINAHL, Cochrane, PsycINFO, PubMed, ScienceDirect, Scientific Electronic Library Online (SciELO), Scopus, SPORTDiscus, and Web of Science databases were searched for relevant papers. Although an increased number of experimental studies are still necessary, people should devote more time to physical activity during social isolation. Guidelines were adjusted by international entities in order to encourage people to remain active, through practice regular physical activity, using alternative strategies such as fitness program applications, exergames, online exercise classes, and even chores. Reduction of prolonged sedentary behavior could contribute to maintain health and improve quality of life during the COVID-19 pandemic.Copyright © Universidad Peruana Cayetano Heredia, Facultad de Medicina Alberto Hurtado. All Rights Reserved.

Methylprednisolone Versus Dexamethasone for Treatment of Severe or Critical Covid-19: A Quasi-Experimental Study (Md Treat)

Intro: Dexamethasone, a corticosteroid, was recently demonstrated to be the only medication capable of reducing mortality in severe COVID disease in the UK's Recovery Trial. There is a need to compare different steroids because it is well recognised that different corticosteroids have varied pharmacodynamic properties. The aim of our study was to compare outcomes in severe or critical COVID-19 when treated with Dexamethasone versus Methyl prednisolone. Method(s): We conducted a retrospective quasi-experimental, non-randomized study to determine whether intravenous or oral dexamethasone reduces mortality compared with intravenous methylprednisolone in patients with severe or critical COVID-19.The study was conducted on all patients aged 18 and over admitted at a 700-bedded academic medical center.The primary outcome was the mortality. The secondary outcome included length of stay. Finding(s): A total of 706 hospitalized patients with moderate to severe COVID- 19 were included in the study. There were n=217 patients in Dexamethasone group, n= 393 patients in Methylprednisolone group and n=96 patients who did not receive steroids.Among the baseline characteristics between the groups, there was no significant difference in median age (55 years in dexamethsone group vs 57 years in methyl prednisolone group p=0.09). There was male predominance in methylprednisolone group (74% versus 54% p<0.001) and a greater proportion of patients who required invasive mechanical ventilation (13.7% versus 3.2% p<0.001). Mortality was found to be significantly higher in methylprednisolone group compared to dexamethasone group on univariate logistic regression analysis (13.7% versus 3.2% p<0.001) and longer length of stay (7 days versus 4 days p<0.001). In multivariable model, dexamethsone was found to be associated with lower risk of mortality (aOR: 0.24;95% CI: (0.09- 0.62)(p=0.003) and lesser length of stay (aOR: 0.87;95% CI: (0.82-0.92) (p<0.001). Conclusion(s): Dexamethasone was associated with lower mortality and lesser length of stay when compared to Methyl prednisolone in moderate to critical COVID-19.Copyright © 2023

Significance of"Qingfei" and "Paidu" of Qingfei Paidu Decoction in Treatment of COVID-19.

Traditional Chinese medicine(TCM)has played an important role in the prevention and treatment of novel coronavirus disease 2019(COVID-19). Qingfei Paidu decoction, as a general prescription of Diagnosis and Treatment Protocol for Novel Coronavirus Pneumonia from the sixth to eighth versions, has been proved effective clinically and is suitable for mild, moderate, severe, and critical patients. It can significantly improve clinical symptoms such as fever, cough, asthma, fatigue, etc. On the basis of the findings of relevant research papers, this paper summarized the TCM understanding of COVID-19, including etiology, pathogenesis, disease location, and treatment, and concluded that the disease is caused by the pestilential Qi, localized in the lungs, and can affect the five organs. It is mainly characterized by coldness, dampness, heat, toxicity, stasis, and deficiency. In response to the etiology and pathogenesis of the disease, the therapeutic principles at all stages are dominated by the elimination of pathogens and removal of toxicity. According to the stages of disease development, the treatment should combine the severity of the disease and the course of the disease with the TCM syndromes. Furthermore, from the clinical application of Qingfei Paidu decoction, this paper discussed the therapeutic intention of "Qingfei(clearing of lungs)" and "Paidu(removal of toxicity)". Qingfei Paidu decoction can clear the pathogenic toxin in the lungs and eliminate external pestilential Qi, which is in line with the therapeutic principles for this pandemic by regulating the triple energizer and protecting healthy Qi using both coldness and warmth to treat both the symptoms and the root cause. Additionally, the experimental research progress on Qingfei Paidu decoction and its modified prescriptions were summarized. As studied, this prescription can inhibit cytokine storm, moderate the overactive immune response, potentiate the immune function and anti-viral ability of the body, and exert its effect on COVID-19 with multiple components, multiple targets, multiple pathways, and multiple biological functions. In conclusion, Qingfei Paidu decoction, as a core prescription for the treatment of COVID-19, can rapidly contain the development of COVID-19, which has been confirmed in terms of TCM theory, clinical efficacy, and experimental research.Copyright © 2022, China Academy of Chinese Medical Sciences Institute of Chinese Materia Medica. All rights reserved.

Zooanthropogenic potential of SARS-CoV-2 virus: Implications for vaccine-mediated immunity

The human pandemic caused by Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that started in December, 2019 is still continuing in various parts of the world. The SARS-CoV-2 has evolved through sporadic mutations and recombination events and the emergence of alternate variants following adaptations in humans and human-to-animal transmission (zooanthraponosis) has raised concerns over the efficacy of vaccines against new variants. The animal reservoir of SARS-CoV-2 is unknown despite reports of SARS-CoV- 2-related viruses in bats and pangolins. A recent report of back-andforth transmission of SARS-CoV-2 between humans and minks on mink farms in the Netherlands has sparked widespread interest in zooanthroponotic transmission of SARS-CoV-2 followed by reemergence to infect human populations. The risk of animal to human transmission depends on virus-host interaction in susceptible species that may be short-term or long term risks. The short term risk might be due to infection to humans during the viremic stage in susceptible animals. The long term risk might be either due to persistence of the virus at population level or latency of infection leading to risk of evolution and re-emergence of the virus. Experimental studies have identified a range of animals that are susceptible and permissive to SARS-CoV-2 infection viz. cats, ferrets, hamsters, mink, non-human primates, tree shrews, raccoon dogs, fruit bats, and rabbits. The health impacts of SARS-CoV-2 infection in animals are unknown and it is likely that other susceptible species have not been discovered yet. Apart from farmed animals, stray cats and rodents have been identified as a potential opportunity for ongoing transmission in intense farming situations. Recognizing animal species that are most susceptible to infection is the first step in preventing ongoing transmission from humans. Minimizing the risk of zooanthraponosis requires multi-sectoral coordination that includes implementation of strict biosecurity measures such as controlled access to farms that house susceptible animals, bio-secure entry and exit protocols, disinfection protocols in farm, down time for animal transport vehicles and daily assessments of human handlers for exposure to SARS-CoV- 2. Hence, active surveillance in animal species that are prioritized based on risk assessment need to be initiated in coordination with health and environment sectors for early identification of emerging and re-emerging variants of SARS-CoV-2 virus in animals.

Effect of pulmonary rehabilitation program on post hospitalization severe COVID-19 patients (Experimental study)

Background: COVID-19 infection was discovered to be the major global cause of a serious respiratory illness toward the end of 2019. The majority of COVID-19 patients experience mild disease, while about 14% go on to have severe disease and 6% end up in critical condition. An evidence-based standard of therapy called pulmonary rehabilitation includes exercise-training, education, and behavior modification to help people had a lung illness feel better physically and mentally. Aim(s): current study aimed to evaluate the effect of pulmonary rehabilitation program on severe post covid19 patients (post hospitalization) regarding pulmonary function tests and dyspnea score. Method(s): Randomized control experimental study design enrolled 100 patients of post hospitalization due to severe COVID 19 infection. Dyspnea score, Spirometry and 6-minute walk test were performed upon discharge. Pulmonary rehabilitation program in the form of respiratory exercises and walking exercise was done to 50 patients. Follow up assessment of the same parameters was done 6 weeks after the program. Other 50 patients had no pulmonary rehabilitation program to them. Result(s): Post COVID-19 cases in the experimental group show much improvement in percentage of normal breathing score (mMRC) 30% versus no cases in control group. In addition, the experimental group showed a significant higher percentage of normal spirometry findings (66% versus 28% in control group). As regards oxygen saturation, 6MWT score and distance, it showed a higher mean after practicing the exercise program. Conclusion(s): pulmonary rehabilitation program was effective in achieving much improvement in recovery of severe cases of COVID 19 infection.Copyright © 2021 Muslim OT et al.

Evaluation of a nutrition education and cooking programme (NEST) in vulnerable adults who are at high risk of food insecurity

Within Australia, the prevalence of food insecure individuals increased from 2.6 million in 2014-2016 (10.8%) to 3.1 million in 2018- 2020 (12.3%) due to the COVID-19 pandemic.(1) OzHarvest is a not-for-profit organisation that prioritises food salvaging, food waste prevention and nutrition education.(2) OzHarvest's education sector facilitates a programme known as Nutrition Education Skills Training (NEST). NEST is a 6-week programme providing weekly workshops of 2.5-hour duration offering skills training on cooking simple, healthy, and affordable meals to adults at risk of food insecurity. This study aimed to determine the immediate and longerterm impacts of participation in NEST. A quasi-experimental study with pre-post surveys (n = 258) and follow-up surveys (n = 20) was conducted from June 2019 to July 2022. Survey results were obtained from NEST program participants (18 years) from Adelaide Canberra, Melbourne, Newcastle, Queensland, and Sydney. Baseline (pre-) and post-surveys (at program completion) were administered to participants, with an option for a 6-month follow-up survey. Participants were required to complete both surveys to be eligible for this study. Questionnaires included 23 core questions adapted from previous studies,(3) allowing evaluation of nutrition knowledge confidence and self-efficacy, shopping, and food preparation behaviours, and eating behaviours. Food security was assessed using the standard 6-item indicator set for classifying households by food security status level. Using paired t-tests, Shapiro Wilks, and Wilcoxon sign-ranked tests for pre and post survey data, participants demonstrated overall improvement in nutrition knowledge (p < 0.001), confidence and self-efficacy (n = 222;p < 0.001) and food preparation behaviours (p < 0.001). The intake of discretionary foods overall decreased (p < 0.001) while fruit, vegetable and water intake increased (p < 0.001). Food security improved from 57% to 68% immediately within the population (p < 0.001). Using RMANOVA and Shapiro Wilks tests, the 6-month survey results were compared to the pre surveys suggested longer lasting improvements in nutrition knowledge (p < 0.001), cooking confidence (n = 8;p = 0.033), food preparation behaviours (p = 0.003), and increased vegetable intake (p = 0.032) and fruit intake (p = 0.012) Participation in OzHarvest's NEST programme results in short-term improvements in food security levels and dietary behaviours Over the longer term, these changes were sustained but to a lesser degree, indicating that systemic changes are required to address underlying socioeconomic disadvantage.

A new tourism paradigm and changes in domestic tourism for married Koreans in their 30s and 40s

Due to the prolonged COVID-19 outbreak, more people are traveling domestically to relieve psychological fatigue. This study aimed to present a new tourism paradigm for the domestic tourism industry in Korea by identifying the changing tourism demand and patterns/preference of tourists due to COVID-19. Through comparative analysis of domestic travel before and after COVID-19, 632 samples were analysed using the 5W1H method. The results revealed the preferences of various tourism attributes such as travel companion, time, duration, distance, lodging facilities, and destination activity, which provided many practical implications for the tourism industry. The study results show that Korean families prefer shorter travel itineraries and destinations close to home after the COVID-19 pandemic. Preference for days of travel, accommodation, and major activities at destinations did not change, but were significantly affected. This study presents evidence that can provide a practical direction to the current situation thereby, enriching the extant tourism literature.

Effectiveness of personalized ventilation in reducing airborne infection risk for long-term care facilities

Throughout history, the human population has experienced major outbreaks of infectious diseases. In December 2019 the previously unknown SARS-CoV-2 virus emerged, which had a huge impact globally. Residents of long- term care facilities (LTCFs) showed to be highly susceptible to infection due to their frailty. Respiratory infectious diseases, such as COVID-19, can spread among others via the airborne transmission route. This is caused by sharing the same indoor environment. To reduce the risk of infection via the airborne route, it is important to consider ventilation and other building services system measures, including personalized ventilation (PV). PV has the potential of being a suitable solution for LTCFs, as it could still allow interaction between residents and visitors in the common rooms, which is regarded very important from a mental health perspective. To identify the potential of PV in the context of infection risk, a laboratory experiment was conducted to investigate its effectiveness on the infection risk reduction. The research was performed in a controlled climate chamber. In the experiment a person was mimicked and positioned close to a PV system that provided filtered recirculated air. A particle source maintained a constant particle concentration in the room. The performance of the PV system was measured through the particle concentration near the breathing zone as compared to the room concentration. Several design parameters were investigated. Translating the outcomes to a fictive (equivalent) ventilation rate, the Wells-Riley equation was applied to determine the infection risk. The outcomes indicated that, in this laboratory setting, the PV system can reduce the risk of an infection up to 50%. The performance is affected by the distance of the supply head to the breathing zone, the angle of the supply head, airflows in the room and the location of the particle source. To further optimize the system and allow its application in LTCFs, several aspects still need further attention, such as mobility/placing the person, the breathing pattern of the user and factors influencing the comfort and use. © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

Effects of a brief behavioural cognitive e-therapy for emotional alterations, and inflammation in COVID-19 survivors

Background: The cellular inflammation generated by SARS-COV-2 has been linked with different psychological impairments to long-term. The Mindfulness-based cognitive therapy can generate positive changes in these patients. Aim(s): To know the effects of a brief behavioural cognitive e-therapy on emotional symptoms, and cellular inflammation in COVID-19 survivors. Method(s): A quasi-experimental study was carried out. Participated two groups of survivors COVID-19 patients;experimental group (TG;4) and wait-list group (WLG;6). Both groups were evaluated using The General Anxiety Disorder Questionnaire, the Patient Health Questionnaire, and the brief Davidson Trauma Scale. Cellular inflammation was evaluated by an assessment of salivary IL-6 in a three-phase paradigm: baseline, stress, and recovery. The TG has received eight virtual mindfulness-based cognitive therapy sessions lasting two hours. The statistical analysis was performed using the software SPSS version 26. Result(s): The average age was about 58+/-11.57 years (TG), and 44.33+/- 17.18 years (WLG). The TG showed a only a clinical differences in the psychological symptoms (anxiety;Mepre = 15.50, Mepost = 8, depression;Mepre =13, Mepost =6 and PTSD;Mepre = 10, Mepost = 5.50), and in the il-6 levels (Base line Mepre = 7.11 pg/mL, Mepost = 16 pg/mL, stress phase Mepre = 10.07 pg/mL, Mepost = 8.77 pg/mL, and recovery phase Me = 14.08 pg/mL, Me = 16.29 pg/mL). Conclusion(s): This type of therapy can helps to reduce the levels of the emotional alterations and generate a modulation of the il-6 levels. The effects of this type of treatment need to continue in research as a therapeutic option for the population that survives COVID-19.

Neurovirulence of SARS CoV2: From Clinical Data to Preclinical Neu-ropsychological Exploration

Introduction: COVID-19 pandemic represents a major health issue caused by SARS CoV2, a human coronavirus. Since the outbreak of this pandemic, the literature on SARS CoV-2 has grown differentially, with increased awareness of extra-respiratory symptoms, including neurological symptoms. Method(s): Review based on studies published from December 2019 to June 2020. Results and Discussion: This review discusses the neurological aspect of SARS CoV2, including the suggested mechanism involved. Neurological disorders are cited in addition to emerging experimental models with viral involvement. Conclusion(s): There is a need for further investigation to clarify how it can lead to the onset of acute and chronic neurological disorders, mentioning the importance of experimental studies in neuropsy-chopharmacology.Copyright © 2022 Bentham Science Publishers.

Filtration Performance and Fiber Shedding Behavior in Common Respirator and Face Mask Materials

Wearing respirators and face masks is effective for protecting the public from COVID-19 infection. Thus, there is a need to evaluate the performance of the commonly used respirators and face masks. Two experimental systems were developed to investigate seven different mask materials, which have a fiber size range from 0.1 µm (100 nm) to 20 µm (20,000 nm). One of the systems is a computer-controlled setup for measuring the filtration performance, including size-dependent filtration efficiency and pressure drop, while the other system is for testing the fiber shedding behavior of the materials. The technique of scanning electron microscope (SEM) was applied to observe the dimensions and structures of those materials, which are made of nonwoven-fabrics electret-treated media, cotton woven fabrics, or nanofiber media. The study indicated that the 3M N95 respirator has the best overall filtration performance with over 95% efficiency and low pressure drop of 74.1 Pa. The two commercial cotton face masks have the worst filtration performance in general, with a filtration efficiency of around 25%. No broken fibers from by the seven tested respirator and face mask materials were discovered;however, dendrite structures likely shed by the SHEMA97 face mask with a size comparable to its nanoscale fibers were identified. The reason for this phenomena is presented. © 2023, AAGR Aerosol and Air Quality Research. All rights reserved.

The Effect of Play Activities for COVID-19 Positive and MIS-C Pediatric Patients on the Anxiety and Fear of Children and Their Parents

Aim: This study aims to determine the effects of play activities for COVID-19 positive and MIS-C pediatric patients on the anxiety and fear of children and their parents. Method(s): This is an experimental study that was prepared through STROBE. The study population consisted of 38 children treated in a university hospital COVID-19 unit. The Children's Anxiety Meter-State and the Children's Fear Scale were administered before and after the play activities. The parents' fear and anxiety were assessed using the COVID-19 Phobia Scale and the Beck Anxiety Inventory. The book and coloring set was prepared in advance and delivered to the experimental group in a package. After the sets were given to the parents, the parents read the book to their children the same day. Afterward, they were asked to color pictures of coronavirus precautions together with the children. SPSS 22.00 package program was used to analyze the study data. The Mann-Whitney U test was used to compare independent groups, and Wilcoxon analysis was used to analyze dependent variables before and after the play activities. Result(s): Based on the children's anxiety and fear scores in the experimental group, significant differences were found before and after the play activities and significant differences between the anxiety scores (<0.05) of parents and children. However, no significant difference was found between post-play anxiety and fear scores of children in the experimental group and the scores of the control group. Discussion(s): The experimental group had low mean anxiety and fear scores after the play activities. Play activities should be used to reduce the anxiety and fear of children who are treated in isolation in hospitals during the COVID-19 pandemic. Even if children are restricted to isolation rooms, their daily routines should be maintained, and their parents should be supported.Copyright © 2021 Croatian Paediatric Society. All rights reserved.

Enveloped Viruses: Pathogenetic Targets for Cyanobacterial Lectins.

Lectins are a group of highly specific carbohydrate-binding proteins with a wide spectrum of action, involved in the so-called <<first line>> of body defense. These unique biomolecules show high specificity for various mono- and oligosaccharides, primarily for viral and bacterial glycoconjugates. Cyanobacteria lectins are effective against enveloped viruses and are an appealing alternative to existing synthetic drugs. Virtually complete absence of resistance formation in viruses to these compounds is known. The purpose of this review is to analyze, summarize, and discuss the results of experimental studies in vivo and in vitro, illustrating the mechanisms of action and antiviral effects of lectins obtained from cyanobacteria in relation to the most dangerous and socially significant viruses: SARS-Cov-2, HIV, Ebola viruses, influenza, and hepatitis C. In addition, the article outlines some of the challenges that must be overcome in order to obtain effective antiviral drugs in the future.Copyright © Team of Authors, 2022.

Training impact on COVID-19 among health care workers

Background: Abderrahmane Mami Hospital of pneumophtisiology was dedicated COVID-19 hospital since the beginning of COVID-19 pandemic. Health care workers (HCW) were led to provide medical care to the consulting or hospitalized patients suffering from a very contagious and unknown disease. A training was carried out to initiate good attitudes in order to respond to this emergent disease care. The purpose of this study was to evaluate the impact of one training session on the knowledge of HCW about SARS-CoV-2 and the appropriate preventive measures. Method(s): A quasi experimental study was carried out on march 2020 among Abderrahmane Mami HCW. A test containing 10 items was distributed for the participants before and after the training sessions. Result(s): The total number of participants was 226. The number of filled questionnaires before was 139 (54.7%) and 115 (45.3%) after. women represented 79%. The average age was 37+/-11.4 years. The training helped enhancing knowledge about the contagiosity which has raised from 30% to 60% (p=0.01, OR:3.142 [1.146-8.612]) and the mortality from 79.2% to 95% (p<10-3, OR: 0.750[0.582-0.966]). Conclusion(s): The awareness training has helped enhancing the knowledge of health professionals about a lot of COVID-19 aspects. Training in the workplace must be oriented, actualised and repeated in order to fill gaps of the preventive measures in pandemic time.

A Note on the Potential BCG Vaccination - COVID-19 Molecular Link

Objective: Our goal was to elucidate a potential molecular link between the past and current tuberculosis vaccine Bacillus Calmette-Guerin (BCG;a live attenuated strain of Mycobacterium bovis) immunization policies and COVID-19. Method(s): Our sequence homology analyses have demonstrated that there is an intriguing level of sequence homology between a few of the BCG and Sars-CoV-2 proteins. Result(s): The data suggest that the BCG-specific memory B-cells that are preserved in BCG-vaccinated patients cross-recognize SARS-CoV-2 and that this cross-recognition may affect the virus proliferation and COVID-19 severity. Conclusion(s): Our results can stimulate the sharply focused follow-up experimental studies.Copyright © 2020 Bentham Science Publishers.